8 DECEMBER 2025IN MY OPINIONElectrophysiology at the Core of Next-Gen Eye Care SolutionsBy Minzhong Yu, Director, Ophthalmic Electrophysiology, Department of Ophthalmology, University HospitalsBRINGING FUNCTIONAL VISION TESTING INTO CLINICAL PRACTICEMinzhong Yu's career has been shaped by several defining moments. During his master's, doctoral, and postdoctoral training in visual electrophysiology, he witnessed firsthand how technologies such as the electroretinogram (ERG) and visual evoked potential (VEP) could detect dysfunction long before anatomical changes became visible. Later, when he began working directly with patients--particularly those with inherited retinal diseases or ambiguous visual complaints--he fully recognized the irreplaceable role of objective functional testing. These experiences cemented his conviction that electrophysiological testing should serve as a core pillar of ophthalmic diagnostics rather than remain a niche specialty. Ophthalmic electrophysiology is transitioning from a research-dominated field to a more integral part of clinical practice. Advances in multifocal ERG, pattern ERG and quadrant VEP have allowed for region-specific, cell-specific and pathway-specific assessment of retinal and optic nerve function. These tools are increasingly valuable in early diagnosis of diseases like retinitis pigmentosa, cone-rod dystrophy, optic neuropathies and even functional vision loss.Critically, electrophysiology provides objective and quantifiable functional biomarkers--complementing OCT, fundus imaging and genetics. This is especially important for early-stage Minzhong Yu
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