Sakai Clinic 62
Specialists in Natural Beauty Enhancement

Sakai Clinic 62 is a trailblazer in redefining skin and facial enhancement treatments through a fusion of dentistry and cosmetic medicine.

Japan’s first clinic to seamlessly integrate orthodontics, aesthetic dentistry, cosmetic dermatology, regenerative medicine and immunotherapy, Sakai Clinic is establishing a new paradigm in aesthetic care.

It embraces a holistic approach in orthodontics, factoring in bone structure, jaw positioning, gum color and profile to achieve harmonious, natural-looking enhancements. Cutting-edge regenerative treatments restore and revitalize skin and oral health, preserving youthfulness. A Type 2 approval under Japan’s act on ensuring the safety of regenerative medicine affirms its compliance with safety regulations. All treatments are delivered in a welcoming environment where clients receive personalized attention.

“Our aim is to deliver treatments that help our clients regain their natural beauty,” says Dr. Mari Sakai, chairman.

Soon after beginning her medical journey in orthodontics, Dr. Sakai recognized the limitations of conventional treatments in achieving balanced facial aesthetics. Exploring complementary approaches that could enhance the outcomes, she became the first dentist in Japan to qualify as an instructor for hyaluronic acid and botulinum toxin injections, expanding her expertise beyond traditional dentistry. Today, she integrates both disciplines, offering clients a comprehensive, results-driven approach to facial rejuvenation.

Restoring Skin and Oral Health Naturally

A focus on enhancing and harnessing the regenerative power of the human body is key to Sakai Clinic’s approach. The therapies go beyond anti-aging techniques to promoting skin rejuvenation, tissue repair and oral health restoration.

A signature treatment is telomere injections and infusions. As cells age, telomeres shorten, leading to a decline in regenerative capacity, which contributes to visible signs of aging. Sakai Clinic’s telomere injections are designed to restore the self-replicating ability of aged stem cells and damaged DNA to restore cellular vitality. Patients have reported visible improvements in skin texture, reduced fine lines, slowed graying of hair, decreased swelling and even weight loss. A recently completed clinical trial demonstrated that this treatment offers improvement for patients with mild dementia. An additional formulation activates macrophages to optimize its benefits. While these cells play a vital role in maintaining health, excessive activation can lead to inflammatory diseases such as arthritis and allergies. Sakai Clinic’s telomere infusion balances macrophage activity to prevent harmful responses.

The treatment benefits extend to enhanced brain function, regulated immune responses and improved physiological health. Activating the sirtuin gene promotes hemoglobin synthesis, protein and nucleic acid biosynthesis and provides antioxidant and anti-arteriosclerosis benefits. It also regulates cell proliferation and differentiation, making it effective in managing conditions like terminal cancer, atopy and post-viral complications.

U.S. patents were awarded to Telomere injections and infusions for their advanced regenerative properties. Safe for all, including pregnant women, they offer superior benefits compared to high-concentration vitamin C or glutathione drips. Most patients experience significant improvements after undergoing monthly treatments for a minimum of four to six months.

Another distinctive treatment is fibroblast regeneration therapy. Fibroblasts are crucial in reducing fine lines, restoring elasticity and preventing sagging of skin. Sakai is the only clinic in Japan that has been approved to use mucosal fibroblasts for skin regenerative medicine.

Unlike conventional methods of collecting fibroblasts or mesenchymal stem cells from behind the ear, Sakai Clinic extracts fibroblasts from the oral mucosa, eliminating external scarring and the need for sutures. Since oral mucosal fibroblasts are more active than those taken from behind the ear, they enhance regenerative effects for smoother, younger-looking skin.

Oral regenerative medicine treats conditions such as receding gums, periodontal disease and gum discoloration. It naturally stimulates tissue regeneration, improving oral health and aesthetics without surgical intervention.

Expanding its portfolio, Sakai Clinic uses NK cell therapy and autologous adipose-derived stem cell therapy for enhanced rejuvenation. In NK cell therapy, a patient’s blood is collected, and NK cells are multiplied and activated using the latest cultivation technology. In approximately three weeks, the cells expand several thousand times in a sterile environment before being reintroduced into the body.

When administered via IV drip, these cells migrate to damaged areas, facilitating tissue repair and regeneration. This therapy is particularly effective for diabetes, with up to 100 million cells administered per session. For more targeted applications, such as facial rejuvenation, neck and skin treatments, oral health and hair restoration, higher doses of up to 1.6 billion cells can be delivered in a single session.

Visible Results, Lasting Impact

Sakai Clinic’s advanced regenerative treatments have helped patients regain their natural beauty and confidence. One patient, severely injured in an accident, struggled with scars around her mouth and eyebrow that affected her appearance. Rather than opting for traditional plastic surgery, she underwent three procedures using bone marrow stem cell supernatant fluid. After the treatment, the scars were nearly unnoticeable, and her facial harmony and confidence was restored.

In another instance, a 60-year-old woman felt self-conscious about wrinkles around her knees, which limited her fashion choices. Through autologous fat grafting, she achieved smoother, youthful-looking skin, allowing her to wear skirts again with confidence. Inspired by the results, she also underwent fat grafting on her breasts and hands, with remarkable outcomes.

Cutting-edge anti-aging treatments, such as Volnewmer, InMode and Morpheus8, further strengthen Sakai Clinic’s capabilities. It also offers Shiratama, high-concentration Vitamin C and detox infusions designed to relieve hangover and improve liver function.

Regenerative treatments at Sakai Clinic utilize an advanced culture medium developed with innovative biotechnology. This medium contains no animal-derived ingredients, reducing allergy risks, and is FDA-recommended for safety.

To ensure the highest safety and efficacy, the clinic adheres to strict quality control standards. Only European Fetal Bovine Serum is used, ensuring purity and reliability. The manufacturing facility complies with ISO 9001 standards, guaranteeing full traceability of raw materials. Every batch undergoes rigorous quality inspections.

Addressing Function and Aesthetics through Orthodontic Innovation

Orthodontic treatments are the cornerstone of Sakai Clinic. Its most distinctive offering is a technique that achieves osteotomy-level correction without the need for bone cutting.

Branded as Invisa Beauty, the treatment combines the principles of Invisalign, a clear aligner orthodontic method, with Dr. Sakai’s specialized contour and skeletal correction techniques. Unlike traditional orthodontic approaches that prioritize only tooth alignment, Invisa Beauty considers the balance of the entire face.

The technique works by gradually shifting each tooth to create the desired alignment. In conventional osteotomy, the bone is cut by 7 to 8 mm to reposition the jaw. Invisa Beauty accomplishes similar results without surgery. This approach reduces discomfort and lowers the risk of facial sagging, preserving a more natural appearance.

“Beyond straightening the teeth, we balance the skin and muscles to correct the entire face,” says Dr Sakai.

While the treatment typically takes more than two years, it offers the significant advantage of eliminating the need for surgeries. For most patients, appointments every three to four months are sufficient, but in severe cases, more frequent clinical visits may be required.

The transformative impact of Invisa Beauty is best illustrated through real patient experiences. One involved a patient who initially underwent Invisalign treatment at another clinic, where four teeth had already been extracted. Over time, her cheeks appeared gaunt, and her face became longer and narrower. Seeking a solution, she turned to Sakai Clinic.

At the time of her consultation, she was still in the middle of orthodontic treatment, with her back teeth not yet aligned. She also habitually pushed her tongue forward, causing her upper and lower front teeth to protrude slightly. Through Invisa Beauty, her treatment was carefully adjusted to address both functional and aesthetic concerns.

Post-treatment, the gauntness in her cheeks disappeared, resulting in a fuller, more youthful appearance. Her jawline had shortened, giving her a smaller and more proportionate face. A refined profile contributed to a naturally elegant facial balance.

Transformative Beauty Backed by Personalized Guidance

Sakai Clinic ensures that every patient feels welcomed and is at ease. The clinic fosters a warm and approachable environment where patients are genuinely cared for. The staff prioritizes personal connections, engaging with patients in a friendly and supportive manner, making even first-time visitors feel comfortable.

Individualized counseling sessions ensure each patient receives personalized guidance. Recognizing that truly effective treatment requires technical precision and a deep understanding of patient’s personal goals, Dr. Sakai assesses and recommends tailored treatments, a skill honed through extensive experience.

These consultations, which last for an hour, provide an opportunity to uncover the unique qualities that make each patient naturally beautiful—qualities they may not have noticed themselves. Based on these insights, treatment recommendations are provided to enhance natural beauty, rather than altering it.

While orthodontics remains her core specialty, Dr. Sakai has collaborated with distinguished specialists across various disciplines to develop a system that delivers a comprehensive approach to beauty. Once a treatment plan is determined, the most suitable specialist from the team is assigned to carry out the procedure. Dr. Sakai personally oversees treatments in orthodontics, cosmetic dentistry, regenerative medicine and immunotherapy, while procedures such as thread lifts or double eyelid surgery are assigned to highly skilled partner doctors.

To ensure a seamless client experience, the clinic has established clear communication among the team. Every doctor and staff member involved in the treatment is aligned with patients’ wishes and goals, allowing them to work together in harmony.

Adopting a multidisciplinary approach to enhancing natural beauty, Sakai Clinic 62 continues to set new benchmarks in orthodontic and aesthetic medicine.